EFFECT OF NEDOCROMIL SODIUM PRETREATMENT ON THE IMMEDIATE AND LATE RESPONSES OF THE AIRWAY TO SEGMENTAL ANTIGEN CHALLENGE

Citation
Wj. Calhoun et al., EFFECT OF NEDOCROMIL SODIUM PRETREATMENT ON THE IMMEDIATE AND LATE RESPONSES OF THE AIRWAY TO SEGMENTAL ANTIGEN CHALLENGE, Journal of allergy and clinical immunology, 98(5), 1996, pp. 46-50
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology,Allergy
ISSN journal
0091-6749
Volume
98
Issue
5
Year of publication
1996
Part
2
Supplement
S
Pages
46 - 50
Database
ISI
SICI code
0091-6749(1996)98:5<46:EONSPO>2.0.ZU;2-K
Abstract
In many patients with asthma, exposure to allergen results in worsenin g symptoms, pulmonary dysfunction, and increased airway inflammation. In this study, segmental allergen challenge and bronchoalveolar lavage were used to evaluate the airway responses at 5 minutes and 48 hours and to study the extent of inhibition of the response by pretreatment with nedocromil sodium in eight subjects with allergic asthma in a dou ble-blind, placebo-controlled trial. At 5 minutes after challenge, ned ocromil sodium pretreatment significantly reduced histamine concentrat ions, with a trend toward a concomitant reduction in tryptase levels. Nedocromil sodium did not affect the increase in total protein, fetal cell counts, or cell concentrations that occurred 48 hours after chall enge but it did significantly reduce eosinophil recruitment. Eosinophi l activation assessed as release of granule proteins, was unaffected. A significant positive correlation was shown between the degree of his tamine reduction at 5 minutes and the degree of reduction of eosinophi l influx at 48 hours, raising the possibility that eosinophil influx i nto the airway may depend on mediators or cytokines released during th e immediate response to allergen.