SNAKE COILED FIBERS IN RAT SOLEUS MUSCLE IN CHLOROQUINE-INDUCED MYOPATHY SHARE IMMUNOHISTOCHEMICAL CHARACTERISTICS WITH AMYLOID DEPOSITIONSIN ALZHEIMERS-DISEASE BRAIN-TISSUE

Citation
K. Tsuzuki et al., SNAKE COILED FIBERS IN RAT SOLEUS MUSCLE IN CHLOROQUINE-INDUCED MYOPATHY SHARE IMMUNOHISTOCHEMICAL CHARACTERISTICS WITH AMYLOID DEPOSITIONSIN ALZHEIMERS-DISEASE BRAIN-TISSUE, International journal of experimental pathology, 78(1), 1997, pp. 1-8
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pathology
ISSN journal
0959-9673
Volume
78
Issue
1
Year of publication
1997
Pages
1 - 8
Database
ISI
SICI code
0959-9673(1997)78:1<1:SCFIRS>2.0.ZU;2-N
Abstract
Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloro quine treated rats. The SCF began to appear in denervated soleus muscl e by 8 days after chloroquine injection. By day 14, typical SCF were o bserved with an unusual swirling pattern of the myofibrils, presenting a bizarre appearance. By day 21 or later, the SCF became less remarka ble, and were fragmented and broken apart to form large vacuoles. Immu nopathological studies demonstrated that the amyloid beta (A beta) and N and C-terminal regions of amyloid precursor protein (APP), and the amyloid associated proteins tested, apolipoprotein E (apoE), SP-40,40, alpha(1)-antichymotrypsin (alpha(1)-ACT), and ubiquitin, which are kn own to be components of amyloid depositions found in Alzheimer's disea se (AD) affected brains, were present in the SCF. ApoE, SP-40,40, alph a(1)-ACT, and ubiquitin are induced following certain cell challenges (e.g. heat shock, various drugs and injury). The significance of APP, A beta, and amyloid associated proteins are discussed in respect to sn ake coiled fibre formations in chloroquine rat myopathy and in the amy loidogenesis of AD.