A CASE-CONTROL STUDY OF REPRODUCTIVE FACTORS AND RISK OF LYMPHOMAS AND MYELOMAS

Citation
A. Tavani et al., A CASE-CONTROL STUDY OF REPRODUCTIVE FACTORS AND RISK OF LYMPHOMAS AND MYELOMAS, Leukemia research, 21(9), 1997, pp. 885-888
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,Hematology
Journal title
ISSN journal
0145-2126
Volume
21
Issue
9
Year of publication
1997
Pages
885 - 888
Database
ISI
SICI code
0145-2126(1997)21:9<885:ACSORF>2.0.ZU;2-S
Abstract
The relationship between reproductive factors and risk of lymphoid neo plasms was investigated in a hospital-based case-control study conduct ed in northern Italy on women with histologically confirmed incident H odgkin's disease (HD) (n = 68), non-Hodgkin's lymphomas (NHL) (n = 180 ) and multiple myelomas (MM) (n = 71), and 448 controls admitted to ho spitals, for acute, non-neoplastic, non-immunological and non-gynecolo gical conditions. The odds ratios (OR) of HD were 0.6 for greater than or equal to 3 pregnancies compared to nulligravidae, and 0.5 for grea ter than or equal to 1 total (spontaneous and induced) abortions compa red to women reporting no abortions. Compared to nulliparae, the OR of HD was 0.9 in parae and 0.3 in those with first birth when aged <20 y ears. The OR of NHL and MM in relation to number of pregnancies, abort ions and births, age at first birth and time since last birth were clo se to unity. Results were similar for the relation between reproductiv e factors and HD in women younger than 50 years. The OR of NHL was abo ve unity (OR 2.2, 95% Cl 1.0 to 4.9) for women aged <50 years reportin g one or more pregnancies as compared to nulliparae, and for women rep orting the last birth since less than 10 years (OR 2.9, 95% Cl 1.1 to 7.4). Early events in pregnancy, including changes in immunological st atus, rather than exposure to female sex hormones are likely mechanism s for the protection of pregnancies and abortions on the risk of HD. ( C) 1997 Elsevier Science Ltd.