USE OF A 5-COMPARTMENT CLOSED MODEL TO DESCRIBE THE EFFECTS OF ETHANOL INHALATION ON THE TRANSPORT AND ELIMINATION OF INJECTED PYRUVATE IN THE RAT

Authors
WU G
Citation
G. Wu, USE OF A 5-COMPARTMENT CLOSED MODEL TO DESCRIBE THE EFFECTS OF ETHANOL INHALATION ON THE TRANSPORT AND ELIMINATION OF INJECTED PYRUVATE IN THE RAT, Alcohol and alcoholism, 32(5), 1997, pp. 555-561
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
0735-0414
Volume
32
Issue
5
Year of publication
1997
Pages
555 - 561
Database
ISI
SICI code
0735-0414(1997)32:5<555:UOA5CM>2.0.ZU;2-7
Abstract
A five-compartment closed model was established using the system of di fferential equations. The completely analytical solution of a five-com partment closed model was found using the Laplace transform. 2-[C-14]P yruvate kinetics were studied in rats without and with inhalation of v aporized ethanol, and were modelled by the five-compartment closed mod el, i.e. injected site, blood, eliminated (CO2)-C-14 in air, eliminate d C-14 in urine and faeces. The kinetic parameters were estimated usin g the analytical solution of the five-compartment closed model to fit eliminated (CO2)-C-14, and C-14 in urine and faeces simultaneously. Th e compartmental analysis showed that the inhalation of vaporized ethan ol can increase 2-[C-14]pyruvate trans-membrane, trans-tissue processe s and oxidation rate. The model developed is useful for general pharma cokinetic and toxicokinetic analysis as well as for studies on ethanol .