HIV-SPECIFIC MUCOSAL AND CELLULAR-IMMUNITY IN HIV-SERONEGATIVE PARTNERS OF HIV-SEROPOSITIVE INDIVIDUALS

Citation
S. Mazzoli et al., HIV-SPECIFIC MUCOSAL AND CELLULAR-IMMUNITY IN HIV-SERONEGATIVE PARTNERS OF HIV-SEROPOSITIVE INDIVIDUALS, Nature medicine, 3(11), 1997, pp. 1250-1257
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Research & Experimental",Biology,"Cell Biology
Journal title
ISSN journal
1078-8956
Volume
3
Issue
11
Year of publication
1997
Pages
1250 - 1257
Database
ISI
SICI code
1078-8956(1997)3:11<1250:HMACIH>2.0.ZU;2-0
Abstract
HIV-specific mucosal and cellular immunity was analyzed in heterosexua l couples discordant for HIV status in serum and in HIV-unexposed cont rols. HIV-specific IgA but not IgG was present in urine and vaginal wa sh samples from HIV-exposed seronegative individuals (ESN), whereas bo th IgA and IgG were observed in their HIV-seropositive partners; antib odies were not detected in low-risk controls. Envelope protein (Env) p eptide-stimulated interleukin-2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) was detected in 9 out of 16 ESNs, 5 out of 1 6 HIV-infected patients and 1 out of 50 controls. Env peptide-stimulat ed PBMCs of ESNs produced more IL-2 and less IL-10 compared with those of HIV-infected individuals; no differences were observed in chemokin e production or in CCR5 expression. These data demonstrate that a comp artmentalized immune response to pathogens is possible in humans and r aise the possibility of protective roles for cell-mediated immunity an d mucosal IgA in HIV-seronegative individuals exposed to HIV.