NONGASTROINTESTINAL MUCOSA-ASSOCIATED LYMPHOID-TISSUE (MALT) LYMPHOMAS - CLINICAL AND THERAPEUTIC FEATURES OF 24 LOCALIZED PATIENTS

Citation
Pl. Zinzani et al., NONGASTROINTESTINAL MUCOSA-ASSOCIATED LYMPHOID-TISSUE (MALT) LYMPHOMAS - CLINICAL AND THERAPEUTIC FEATURES OF 24 LOCALIZED PATIENTS, Annals of oncology, 8(9), 1997, pp. 883-886
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
0923-7534
Volume
8
Issue
9
Year of publication
1997
Pages
883 - 886
Database
ISI
SICI code
0923-7534(1997)8:9<883:NML(L>2.0.ZU;2-N
Abstract
Background: Peripheral B-cell lymphoma of the marginal zone (MALT, loc i-grade), presenting as localized, extranodal disease, usually affects the elderly. The gastrointestinal tract is the most frequently involv ed extranodal location, representing 70% of all MALT lymphomas. Recent ly, numerous other extranodal sites involved by MALT lymphomas have al so been described. Patients and methods: From January 1990 to October 1995, 24 patients with untreated nongastrointestinal low-grade MALT ly mphoma were submitted to treatments ranging from the local approach of radiotherapy and local alpha-interferon (alpha-IFN) administration to chemotherapy The tumours were located in the lung (seven cases), conj unctiva (four cases), lachrymal gland and orbital soft tissue (four ca ses), salivary glands (three cases), skin (three cases), breast (two c ases), and thyroid (one case). All patients had low-grade stage IE tum ours.Results: Chemotherapy was administered in 11 patients (six with l ung, three with salivary gland, one with breast, and one with thyroid locations); radiation therapy was employed in seven patients (three wi th lachrymal gland, three with skin, and one with breast locations); l ocal a-IFN administration was administered in five patients (four with conjunctival, and one with lachrymal gland sites); and surgery was em ployed in one patient with a lung tumour. All patients achieved comple te remissions: three local recurrences and two relapses in other sites were observed. The global five-year survival rate was 100% with a rel apse-free survival rate of 79%. Conclusions. These data confirm the si gnificant efficacy of different therapeutic approaches to specific sit es inbes obtaining a good remission rate for nongastrointestinal local ized low-grade MALT lymphomas.