EFFECTS OF PARATHYROID-HORMONE AND ESTRADIOL ON PROLIFERATION AND FUNCTION OF HUMAN OSTEOBLASTS FROM FETAL LONG-BONE - AN IN-VITRO STUDY

Citation
Xy. Zang et al., EFFECTS OF PARATHYROID-HORMONE AND ESTRADIOL ON PROLIFERATION AND FUNCTION OF HUMAN OSTEOBLASTS FROM FETAL LONG-BONE - AN IN-VITRO STUDY, Chinese medical journal, 107(8), 1994, pp. 600-603
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0366-6999
Volume
107
Issue
8
Year of publication
1994
Pages
600 - 603
Database
ISI
SICI code
0366-6999(1994)107:8<600:EOPAEO>2.0.ZU;2-C
Abstract
The effect of parathyroid hormone (PTH) (0.01 nM-10 nM) and 17 beta-es tradiol (E2, 1 nmol-10 nM) alone or in combination on H-3-thymidine in corporation, alkaline phosphatase and adenylate cyclase activities wer e investigated in human fetal osteoblasts using serum-free monolayer p rimary cultures. Tle results showed that PTH inhibited cell proliferat ion while E2 promoted it. On alkaline phosphatase activity, PTH showed a complex results while E2 were slightly inhibitory. PHT-E2 combinati on suggested that E2 could alter the effect of PTH alone, also potenti ated the anabolic and antagonize the catabolic effects of PTH on bone formation.