SELECTIVE CHRONIC SODIUM OR CHLORIDE DEPLETION SPECIFICALLY MODULATESSUBFORNICAL ORGAN ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR NUMBER IN YOUNG-RATS

Citation
Pe. Ray et Jm. Saavedra, SELECTIVE CHRONIC SODIUM OR CHLORIDE DEPLETION SPECIFICALLY MODULATESSUBFORNICAL ORGAN ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR NUMBER IN YOUNG-RATS, Cellular and molecular neurobiology, 17(5), 1997, pp. 455-470
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences,"Cell Biology",Biology
ISSN journal
0272-4340
Volume
17
Issue
5
Year of publication
1997
Pages
455 - 470
Database
ISI
SICI code
0272-4340(1997)17:5<455:SCSOCD>2.0.ZU;2-3
Abstract
1. We studied the effects of selective chronic sodium depletion of chl oride depletion on atrial natriuretic peptide receptor number in the s ubfornical organ and paraventricular nucleus of young rats. 2. Sodium or chloride depletion decreased plasma levels of atrial natriuretic pe ptide, increased plasma renin activity, and induced extracellular flui d volume contraction, Chloride depletion induced more significant chan ges in extracellular fluid volume contraction than sodium depletion. 3 . In the subfornical organ, atrial natriuretic peptide receptor number significantly decreased (30%) after sodium depletion, while chloride depletion induced a smaller, not statistically significant decrease. C onversely, atrial natriuretic peptide receptors located in the paraven tricular nucleus of young rats were not significantly affected by sodi um or chloride depletion. 4. Water deprivation reversed the decrease i n atrial natriuretic peptide receptors produced by sodium depletion, W ater-deprived sodium-depleted rats actually had higher numbers of atri al natriuretic peptide receptors in the subfornical organ than control rats. These changes were associated with severe extracellular fluid v olume contraction and up regulation of brain vasopressin mRNA steady-s tate levels. Thus, the direction of change in the number of subfornica l organ atrial natriuretic peptide receptors was dependent on the degr ee of extracellular fluid volume contraction. 5. Our results suggest t hat atrial natriuretic peptide receptors located in the subfornical or gan, and not in the paraventricular nucleus, are selectively regulated by sodium depletion and extracellular fluid volume contraction.