ASYMMETRIC-SYNTHESIS OF ALL 4 ISOMERS OF TOGOGRAPHICALLY CONSTRAINED NOVEL AMINO-ACIDS - BETA-ISOPROPYLTYROSINES

Citation
J. Lin et al., ASYMMETRIC-SYNTHESIS OF ALL 4 ISOMERS OF TOGOGRAPHICALLY CONSTRAINED NOVEL AMINO-ACIDS - BETA-ISOPROPYLTYROSINES, Tetrahedron : asymmetry, 8(19), 1997, pp. 3213-3221
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
ISSN journal
0957-4166
Volume
8
Issue
19
Year of publication
1997
Pages
3213 - 3221
Database
ISI
SICI code
0957-4166(1997)8:19<3213:AOA4IO>2.0.ZU;2-6
Abstract
All four stereoisomers of the highly constrained novel amino acid, bet a-isopropyltyrosine, have been synthesized with high stereoselectiviti es (> 90% de) and in 40-50% overall yields by using the optically pure 4-phenyloxazolidinone as a chiral auxiliary via asymmetric Michael ad dition, direct or indirect azidation, hydrogenolysis and demethylation reactions. (C) 1997 Elsevier Science Ltd.