An azoospermic male with an unbalanced translocation between the Y chr
omosome and chromosome 15 was examined in the present study. Testicula
r biopsy found only Sertoli cells only within the seminiferous tubules
of the 35-year-old patient. Chromosome analysis, using the techniques
of G and C banding and fluorescent in situ hybridization revealed an
abnormal karyotype of 46,XY,der(15)t(Y;15)(q12;p11). Deoxyribonucleic
acid (DNA) analysis confirmed the presence of the genes such as DAZ an
d YRRM1 which are known to control spermatogenesis. The cause of sperm
atogenetic dysfunction in this particular patient therefore.