AN AZOOSPERMIC MALE WITH AN UNBALANCED AUTOSOMAL-Y TRANSLOCATION

Citation
A. Yoshida et al., AN AZOOSPERMIC MALE WITH AN UNBALANCED AUTOSOMAL-Y TRANSLOCATION, JPN J HUM G, 42(3), 1997, pp. 451-455
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity
ISSN journal
0916-8478
Volume
42
Issue
3
Year of publication
1997
Pages
451 - 455
Database
ISI
SICI code
0916-8478(1997)42:3<451:AAMWAU>2.0.ZU;2-G
Abstract
An azoospermic male with an unbalanced translocation between the Y chr omosome and chromosome 15 was examined in the present study. Testicula r biopsy found only Sertoli cells only within the seminiferous tubules of the 35-year-old patient. Chromosome analysis, using the techniques of G and C banding and fluorescent in situ hybridization revealed an abnormal karyotype of 46,XY,der(15)t(Y;15)(q12;p11). Deoxyribonucleic acid (DNA) analysis confirmed the presence of the genes such as DAZ an d YRRM1 which are known to control spermatogenesis. The cause of sperm atogenetic dysfunction in this particular patient therefore.