PLASMA-LIPOPROTEIN (A) LEVELS IN MEN AND WOMEN CONSUMING DIETS ENRICHED IN SATURATED, CIS-MONOUNSATURATED, OR TRANS-MONOUNSATURATED FATTY-ACIDS

Citation
Ba. Clevidence et al., PLASMA-LIPOPROTEIN (A) LEVELS IN MEN AND WOMEN CONSUMING DIETS ENRICHED IN SATURATED, CIS-MONOUNSATURATED, OR TRANS-MONOUNSATURATED FATTY-ACIDS, Arteriosclerosis, thrombosis, and vascular biology, 17(9), 1997, pp. 1657-1661
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Peripheal Vascular Diseas
ISSN journal
1079-5642
Volume
17
Issue
9
Year of publication
1997
Pages
1657 - 1661
Database
ISI
SICI code
1079-5642(1997)17:9<1657:P(LIMA>2.0.ZU;2-I
Abstract
Studies that have shown adverse effects of transunsaturated fatty acid s on plasma lipoprotein (a) [Lp(a)] levels have used levels of trans-f atty acid that are higher than those in the average U.S. diet. This st udy was conducted to clarify the effects on Lp(a) of trans-fatty acids levels commonly found in U.S. diets. Lp(a) levels were measured in a double-blind study of 29 men and 29 women who ate 4 controlled diets i n random order for 6 weeks each. Fatty acids represented 39% to 40% of energy. The diets were: (1) Oleic (16.7% of energy as oleic acid); (2 ) Moderate trans (3.8% of energy as trans-monoenes, approximately the trans content of the U.S. diet); (3) High trans (6.6% of energy as tra ns-monoenes); (4) Saturated (16.2% of energy as lauric plus myristic p lus palmitic acids). The Saturated diet lowered Lp(a) levels significa ntly (by 8% to 11%). Compared to the Oleic diet, the trans diets had n o adverse effect on Lp(a) levels when all subjects were considered col lectively. A subset with initially high levels of Lp(a) (greater than or equal to 30 mg/dL), however, responded to the High trans diet with a slight (5%) increase in Lp(a) levels relative to the Oleic and Moder ate trans diets. Thus, in amounts commonly found in the typical U.S. d iet, saturated fatty acids consistently decrease Lp(a) concentrations. The adverse effects of replacing cis-with trans-fatty acids are only suggestive and are restricted to high trans intakes in subjects with h igh Lp(a) levels.