PURIFICATION OF A FACTOR THAT ENHANCES THE ANTIBACTERIAL ACTIVITY OF BETA-LACTAMS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - ITSIDENTIFICATION AS UNDECAPHOSPHOTUNGSTATE

Authors
Citation
Y. Tajima, PURIFICATION OF A FACTOR THAT ENHANCES THE ANTIBACTERIAL ACTIVITY OF BETA-LACTAMS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - ITSIDENTIFICATION AS UNDECAPHOSPHOTUNGSTATE, Journal of inorganic biochemistry, 68(2), 1997, pp. 93-99
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
ISSN journal
0162-0134
Volume
68
Issue
2
Year of publication
1997
Pages
93 - 99
Database
ISI
SICI code
0162-0134(1997)68:2<93:POAFTE>2.0.ZU;2-M
Abstract
Previously, a factor (Factor T) was found in aged mixtures of tungstat e and phosphate, which greatly enhances the antibacterial effects of b eta-lactam antibiotics on methicillin-resistant Staphylococcus aureus. Factor T was purified and identified as undecaphosphotungstate ([PW11 O39](7-)). Undecasilicotungstate ([SiW11O39](8-)), a compound closely related to undecaphosphotungstate, showed a similar enhancing effect. (C) 1997 Elsevier Science Inc.