PURIFICATION OF A FACTOR THAT ENHANCES THE ANTIBACTERIAL ACTIVITY OF BETA-LACTAMS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - ITSIDENTIFICATION AS UNDECAPHOSPHOTUNGSTATE
Y. Tajima, PURIFICATION OF A FACTOR THAT ENHANCES THE ANTIBACTERIAL ACTIVITY OF BETA-LACTAMS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - ITSIDENTIFICATION AS UNDECAPHOSPHOTUNGSTATE, Journal of inorganic biochemistry, 68(2), 1997, pp. 93-99
Previously, a factor (Factor T) was found in aged mixtures of tungstat
e and phosphate, which greatly enhances the antibacterial effects of b
eta-lactam antibiotics on methicillin-resistant Staphylococcus aureus.
Factor T was purified and identified as undecaphosphotungstate ([PW11
O39](7-)). Undecasilicotungstate ([SiW11O39](8-)), a compound closely
related to undecaphosphotungstate, showed a similar enhancing effect.
(C) 1997 Elsevier Science Inc.